Hepatic Fatalities and Valproic Acid
نویسندگان
چکیده
منابع مشابه
Valproic Acid and Fatalities in Children: A Review of Individual Case Safety Reports in VigiBase
INTRODUCTION Valproic acid is an effective first line drug for the treatment of epilepsy. Hepatotoxicity is a rare and potentially fatal adverse reaction for this medicine. OBJECTIVE Firstly to characterise valproic acid reports on children with fatal outcome and secondly to determine reporting over time of hepatotoxicity with fatal outcome. METHODS Individual case safety reports (ICSRs) fo...
متن کاملVALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
متن کاملValproic acid and immune thrombocytopenia.
During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may...
متن کاملValproic acid and pubertas praecox
Precocious puberty refers to the appearance of physical and hormonal signs of pubertal development at an earlier age than is considered normal. In girls, the telltale signs of precocious puberty include any of the following symptoms before 7 or 8 years of age: breast development, pubic or underarm hair development, rapid height growth a growth "spurt", onset of menstruation, acne and "mature" b...
متن کاملValproic acid and gingival disorders
Introduction Valproic acid (Depakine ) is an anti-epileptic drug which is indicated for the treatment of primary generalized epilepsy, partial epilepsy, with focal and psychomotoric symptoms and secondary forms of generalized epilepsia. The mechanism of action of valproic acid has not yet been established, the activity may be related to increased brain concentrations of gamma-aminobutyric acid ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 1996
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-10-4-7